2013-07-01 Lebenslauf Dr. van den Boorn - University of Bonn

2013-07-01 Lebenslauf Dr. van den Boorn - University of Bonn

Dr.  Jasper  Guido  van  den  Boorn   Dr.  Jasper  Guido  van  den  Boorn       Curriculum  Vitae     A.) General  information     Name:       ...

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Dr.  Jasper  Guido  van  den  Boorn  

Dr.  Jasper  Guido  van  den  Boorn      

Curriculum  Vitae

 

 

A.) General  information     Name:       Adress:    

Dr.  Jasper  Guido  van  den  Boorn     Institut  für  Klinische  Chemie   und  Klinische  Pharmakologie   Biomedizinisches  Zentrum  (Geb.  344)   Zimmer  1.OG-­‐020   Sigmund-­‐Freud-­‐Strasse  25   53127  Bonn  

Phone:    

  Desk:  0228-­‐287-­‐51143     Lab:  0228-­‐287-­‐51162  

Email:     [email protected]­‐bonn.de   Birthday:   August  1980     Nationality:     Dutch      

B.)  Scientific  career             Education/Degrees:   1993  –  1999   Gymnasium  (β)  at  the  Rijnlands  Lyceum  in  Oegstgeest   1999  -­‐  2002     Bachelor   program   Biomedical   Sciences   at   the   Free   University   of   Amsterdam   (BSc.  in  Biomedical  Sciences)   2002  –  2004   Master   program   Oncology   at   the   Free   University   of   Amsterdam   (MSc.   in   Oncology)   2005  –  2010     Doctorate   research   project,completed   with   public   defence   of   dissertation.   Research  performed  at  the  Department  of  Dermatology  and  the  Netherlands   Institute  of  Pigment  Disorders,  Academic  Medical  Center  of  the  University  of   Amsterdam  (UvA),  The  Netherlands  (Dr.)        

Dr.  Jasper  Guido  van  den  Boorn   Research  experience:   2005  –  2010   PhD   research   project:   “Vitiligo   pathogenesis   and   immunotherapy   of   melanoma”.  Lab.  of  Exp.  Dermatology  of  the  Academic  Medical  Center  of  the   University   of   Amsterdam   (co-­‐promotor:   Dr.   R.M   Luiten;   Promotores:   Prof.   Dr.   J.D.  Bos  and  Prof.  Dr.  C.J.M.  Melief)   2010  –  2010   Postdoc   on   melanoma   immunotherapy,   Lab.   of   Exp.   Dermatology,   Academic   Medical  Center  of  the  University  of  Amsterdam  (Lab  Dr.  R.M  Luiten,  Prof.  Dr.   J.D.  Bos  and  Prof.  Dr.  C.J.M.  Melief)   since  2011   Team   member   biotech   start-­‐up   ‘ImmunOligo’   GmbH   i.G.   (Prof.   G.   Hartmann   CEO  a.i.);  proof-­‐of-­‐concept  &  pharmacodynamics   since  2011   Junior   research   group   leader   on   tumor   immunotherapy   and   innate   immune   activation,   Dept.   of   Clinical   Chemistry   and   Clinical   Pharmacology,   University   Hospital  Bonn,  Bonn,  Germany  (Lab  of  Prof.  Dr.  G.  Hartmann).     Awards     2011   Scientific  Outreach  Award  (University  of  Amsterdam)   2011   Nomination  for  Dissertation  Award  (Dutch  Society  for  Immunology)     Research  Funding   2011   Bonfor-­‐Forschungskommission   research   grant.   Two   years,   PhD   student   (project  ID:  2011-­‐1-­‐3  /  2012-­‐1-­‐2)   2012   Bayer  Kooperation  research  grant.  Three  years  PhD  student.     Science  &  Society   2010   PLoS  One  article  on  MIC  therapy  combined  with  Doctorate  ceremony  on  July   6,   2010:   Feature   interview   on   Dutch   national   BNR   news-­‐radio,   national   Telegraph   newspaper,   Metro   newspaper,   various   news-­‐   and   science-­‐related   internet  sites  and  -­‐magazines.       Professional  memberships  

           



Association  for  Cancer  Immunotherapy  (CIMT)  



International  Society  for  Extracellular  Vesicles  (ISEV)  



Dutch  Society  for  Immunology  (NVVI)  

Dr.  Jasper  Guido  van  den  Boorn  

C.) Publications     Publications  in  peer-­‐reviewed  journals   Primary  Research   1. WW.  Overwijk,  KE.  de  Visser,  F.  Tirion,  LA.  de  Jong,  T.  Pols,  Y.  van  der  Velden,  J.G.   van   den  Boorn   et  al.   Immunological   and   anti-­‐tumor   effects   of   interleukin-­‐23   as   a   cancer   vaccine  adjuvant:  selective  expansion  of  antigen-­‐specific  CD8+  T  cells  and  depletion   of  bystander  T  cells.  J  Immunol,  2006;176:5213-­‐22.     2. J.G.   van   den   Boorn,  D.  Konijnenberg,  T.A.  Dellemijn  et   al.   Autoimmune  Destruction   of  Skin  Melanocytes  by  Perilesional  T  Cells  from  Vitiligo  Patients.   J  Invest  Dermatol,   2009,  129:  2220-­‐2232.     Featured  in  ‘Clinical  Snippets’  section:  J  Invest  Dermatol,  2009,  129:2081.     3. J.G.   van   den   Boorn,   D.   Konijnenberg,   W.   Douwenga   et   al.   Effective   melanoma   immunotherapy   in   mice   by   the   skin-­‐depigmenting   agent   monobenzone   and   the   adjuvants  imiquimod  and  CpG.  PLoS  One,  2010,  13;5(5):e10626     4. J.G.   van   den   Boorn,   D.I.   Picavet,   P.F.   van   Swieten   et   al.   Skin-­‐depigmenting   agent   monobenzone   induces   potent   T   cell   autoimmunity   towards   pigmented   cells   by   tyrosinase   haptenation   and   melanosome   autophagy.   J   Invest   Dermatol,   2011,   131:1240.   Featured  in  ‘Commentaries’  section:  J  Invest  Dermatol,  2011,  131:1185.   Featured  in  ‘Clinical  Snippets’  section:  J  Invest  Dermatol,  2011,  131:  1178.   Featured  as  full-­‐cover  illustration  on  issue  J  Invest  Dermatol,  2011,  131.     Reviews   5. Pedro  Oyarbide-­‐Valencia,  Jasper   G.   van   den   Boorn  et  al.  Therapeutic  implications   of  autoimmune  vitiligo  T  cells.  Autoimmun  Rev,  2006  5:486-­‐92.   6. J.G.   van   den   Boorn,   I.   Caroline   LePoole   and   Rosalie   M.   Luiten.   T   cell   avidity   and   tuning:   the   flexible   connection   between   tolerance   and   autoimmunity.   Int   Rev   Immunol,  2006,  25:235-­‐58.     7. J.G.   van   den   Boorn,   M.   Schlee,   C.   Coch   and   G.   Hartmann.   SiRNA   delivery   with   exosome  nanoparticles.  Nature  Biotechnology,  2011,  29(4):325-­‐326.   8. J.G.  van  den  Boorn,  Cornelis   J.   Melief   and   Rosalie   M.   Luiten.   Monobenzone-­‐induced   depigmentation:  from  enzymatic  blockade  to  autoimmunity.  Pigment   Cell   Melanoma   Res.  2011,  24(4):  673-­‐679.   9. J.G.   van   den   Boorn,   Winfried   Barchet   and   Gunther   Hartmann.   Nucleic   acid   adjuvants:  toward  an  educated  vaccine.  Advances  in  Immunology.  2012,  114:  1-­‐32.   10. J.G.   van   den   Boorn,   Juliane   Daßler,   Christoph   Coch,   Martin   Schlee,   Gunther   Hartmann.  Exosomes  as  nucleic  acid  nanocarriers.  Advanced  Drug  Delivery  Reviews.   2013,  65(3):  331-­‐335.      

Dr.  Jasper  Guido  van  den  Boorn   Book  Chapters   11. M.  Schlee,  J.  Ludwig,  C.  Coch,  J.G.  van  den  Boorn,  W.  Barchet,  G.  Hartmann.  Synthetic   and   Natural   Ligands   of   RLR.   Nucleic   Acid   Sensors   and   Antiviral   Immunity.   Landes   Bioscience,  S.  Sambhara  &  T.  Fujita  ed.,  2013.     Other  publications   12. J.G.   van   den   Boorn.   Vitiligo   Pathogenesis   and   Immunotherapy   of   Melanoma.   Dissertation,  University  of  Amsterdam,  Amsterdam,  The  Netherlands,  July  6th  2010,   182   pages,   ISBN:   978-­‐94-­‐90371-­‐22-­‐7   (PDF   version   accessible   via   the   University   of   Amsterdam   online   dissertation   repository,   under   http://dare.uva.nl/en/record/341596).     Reviewing   • • •

Referee  for  BMC  Immunology   Referee  for  British  Journal  of  Dermatology   Referee  for  the  Journal  of  the  European  Academy  of  Dermatology  and  Venereology  

Stand:  07/2013